What does Mole Reduction mean? Mole reduction is what I offer as an advanced blemish removal practitioner. I use diathermy in order to reduce down the mole and it’s appearance on the skin. As with any treatment there are important considerations when you are looking to have treatment of a mole for cosmetic purposes. Histology: What is the difference between cutting out a mole and using diathermy to reduce.When a mole is cut out, the entire lesion (including a margin of surrounding tissue) can be sent to a laboratory for histological analysis. This is the gold standard for ruling out anything suspicious. Also of course if the mole is confirmed