Mole Reduction vs Mole Removal: What Is the Difference and What Does Each One Actually Mean? This is genuinely an important question. When someone comes to me wanting to do something about a mole, the first thing I need to establish is what they actually want to achieve, because mole reduction and mole removal are two very different things, medically and practically. Here is what each one means, how they differ, and why the distinction matters more than most people realise. What is mole removal? True mole removal means the complete excision of a mole, including the tissue beneath the skin surface. This is a surgical procedure, carried out by